Organic and Medicinal Chemistry

This section publishes articles in all areas of organic chemistry and medicinal chemistry including organic synthesis, bioorganic chemistry, physical organic chemistry, stereochemistry, structure-activity relationships, synthetic methods, organometallic chemistry, supramolecular chemistry, and natural product chemistry.

Section Editors: Vassya Bankova, Tony James, Simon Lewis, Matthew Todd, Bimal Banik


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  1. Research article

    Synthesis, characterization, X-ray structure, computational studies, and bioassay of novel compounds combining thiophene and benzimidazole or 1,2,4-triazole moieties

    Due to their interesting and versatile biological activity, thiophene-containing compounds have attracted the attention of both chemists and medicinal chemists. Some of these compounds have anticancer, antibac...

    Yahia N. Mabkhot, Salim S. Al-Showiman, Saied M. Soliman, Hazem A. Ghabbour, Murad A. AlDamen and Mohammad S. Mubarak

    Chemistry Central Journal 2017 11:51

    Published on: 9 June 2017

  2. Research article

    Synthesis and insecticidal activity of diacylhydrazine derivatives containing a 3-bromo-1-(3-chloropyridin-2-yl)-1H-pyrazole scaffold

    The diacylhydrazine derivatives have attracted considerable attention in recently years due to their simple structure, low toxicity, and high insecticidal selectivity. As well as 3-bromo-1-(3-chloropyridin-2-y...

    Yanyan Wang, Fangzhou Xu, Gang Yu, Jun Shi, Chuanhui Li, A’li Dai, Zhiqian Liu, Jiahong Xu, Fenghua Wang and Jian Wu

    Chemistry Central Journal 2017 11:50

    Published on: 5 June 2017

  3. Research article

    Synthesis, docking study and biological evaluation of some new thiourea derivatives bearing benzenesulfonamide moiety

    A series of novel N-(2, 6-dimethoxypyrimidin-4-yl)-4-(3-(aryl)thioureido) benzenesulfonamides 3at was synthesized by the addition of N-(2,6-dimethoxypyrimidin-4-yl)-4-isothiocyanatobenzenesulfonamide 2 to the ap...

    Mostafa M. Ghorab, Mohamed S. A. El-Gaby, Aiten M. Soliman, Mansour S. Alsaid, Marwa M. Abdel-Aziz and Mahmoud M. Elaasser

    Chemistry Central Journal 2017 11:42

    Published on: 19 May 2017

  4. Research article

    QSAR studies on PIM1 and PIM2 inhibitors using statistical methods: a rustic strategy to screen for 5-(1H-indol-5-yl)-1,3,4-thiadiazol analogues and predict their PIM inhibitory activity

    Quantitative structure activity relationship was carried out to study a series of PIM1 and PIM2 inhibitors. The present study was performed on twenty-five substituted 5-(1H-indol-5-yl)-1,3,4-thiadiazols as PIM...

    Adnane Aouidate, Adib Ghaleb, Mounir Ghamali, Samir Chtita, M’barek Choukrad, Abdelouahid Sbai, Mohammed Bouachrine and Tahar Lakhlifi

    Chemistry Central Journal 2017 11:41

    Published on: 19 May 2017

  5. Research article

    Synthesis, characterization and evaluation of 1,3,5-triazine aminobenzoic acid derivatives for their antimicrobial activity

    Replacement of chloride ions in cyanuric chloride give several variants of 1,3,5-triazine derivatives which were investigated as biologically active small molecules. These compounds exhibit antimalarial, antim...

    Khadijah M. Al-Zaydi, Hosam H. Khalil, Ayman El-Faham and Sherine N. Khattab

    Chemistry Central Journal 2017 11:39

    Published on: 10 May 2017

  6. Research article

    Antimicrobial and anticancer activity of some novel fluorinated thiourea derivatives carrying sulfonamide moieties: synthesis, biological evaluation and molecular docking

    Various thiourea derivatives have been used as starting materials for compounds with better biological activities. Molecular modeling tools are used to explore their mechanism of action.

    Mostafa M. Ghorab, Mansour S. Alsaid, Mohamed S. A. El-Gaby, Mahmoud M. Elaasser and Yassin M. Nissan

    Chemistry Central Journal 2017 11:32

    Published on: 7 April 2017

  7. Research article

    Modeling and optimization of nanoemulsion containing Sorafenib for cancer treatment by response surface methodology

    The aim of this study is the development of nanoemulsions for intravenous administration of Sorafenib, which is a poorly soluble drug with no parenteral treatment. The formulation was prepared by a high energy...

    Zahra Izadiyan, Mahiran Basri, Hamid Reza Fard Masoumi, Roghayeh Abedi Karjiban, Norazlinaliza Salim and Kamyar Shameli

    Chemistry Central Journal 2017 11:21

    Published on: 2 March 2017

  8. Research article

    Synthesis and protective effect of new ligustrazine-vanillic acid derivatives against CoCl2-induced neurotoxicity in differentiated PC12 cells

    Ligustrazine-vanillic acid derivatives had been reported to exhibit promising neuroprotective activities. In our continuous effort to develop new ligustrazine derivatives with neuroprotective effects, we attem...

    Bing Xu, Xin Xu, Chenze Zhang, Yuzhong Zhang, GaoRong Wu, Mengmeng Yan, Menglu Jia, Tianxin Xie, Xiaohui Jia, Penglong Wang and Haimin Lei

    Chemistry Central Journal 2017 11:20

    Published on: 28 February 2017

  9. Research article

    Characterization of major metabolites of polymethoxylated flavonoids in Pericarpium Citri Reticulatae using liver microsomes immobilized on magnetic nanoparticles coupled with UPLC/MS–MS

    The peels of citrus fruits (Pericarpium Citri Reticulatae, PCR) have long been used in traditional Chinese medicines (TCMs). Polymethoxylated flavonoids (PMFs) were found to be the main components present in ...

    Jun Lei, Ying Xue, Yi-Ming Liu and Xun Liao

    Chemistry Central Journal 2017 11:13

    Published on: 6 February 2017

  10. Research article

    2-Benzyl-benzofurans from the tubers of Ophiopogon japonicus

    The overproduction of nitric oxide (NO) is known to involve in various inflammatory processes. A methanol extract of the tubers of Ophiopogon japonicus was found to strongly inhibit NO production. The present pap...

    Nguyen Hai Dang, Nguyen Dinh Chung, Ha Manh Tuan, Nguyen Van Thanh, Nguyen Tuan Hiep, Dongho Lee and Nguyen Tien Dat

    Chemistry Central Journal 2017 11:15

    Published on: 6 February 2017

  11. Research article

    Synthesis and biological evaluation of the new 1,3-dimethylxanthine derivatives with thiazolidine-4-one scaffold

    The xanthine structure has proved to be an important scaffold in the process of developing a wide variety of biologically active molecules such as bronchodilator, hypoglycemiant, anticancer and anti-inflammato...

    Sandra Constantin, Florentina Geanina Lupascu, Maria Apotrosoaei, Ioana Mirela Vasincu, Dan Lupascu, Frederic Buron, Sylvain Routier and Lenuta Profire

    Chemistry Central Journal 2017 11:12

    Published on: 1 February 2017

  12. Research article

    Cheminformatics studies to analyze the therapeutic potential of phytochemicals from Rhazya stricta

    Rhazya stricta is a unique medicinal plant source for many indole alkaloids, non-alkaloids, flavonoids, triterpenes and other unknown molecules with tremendous potential for therapeutic a...

    Abdullah Y. Obaid, Sreedhara Voleti, Roop Singh Bora, Nahid H. Hajrah, Abdulkader M. Shaikh Omer, Jamal S. M. Sabir and Kulvinder Singh Saini

    Chemistry Central Journal 2017 11:11

    Published on: 30 January 2017

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