Organic and Medicinal Chemistry

This section publishes peer-reviewed open access articles in all areas of organic chemistry and medicinal chemistry including organic synthesis, bioorganic chemistry, physical organic chemistry, stereochemistry, structure-activity relationships, synthetic methods, organometallic chemistry, supramolecular chemistry, and natural product chemistry.

Section Editors: Vassya Bankova, Tony James, Simon Lewis, Matthew Todd, Bimal Banik


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  1. Research article

    Characterization of major metabolites of polymethoxylated flavonoids in Pericarpium Citri Reticulatae using liver microsomes immobilized on magnetic nanoparticles coupled with UPLC/MS–MS

    The peels of citrus fruits (Pericarpium Citri Reticulatae, PCR) have long been used in traditional Chinese medicines (TCMs). Polymethoxylated flavonoids (PMFs) were found to be the main components present in ...

    Jun Lei, Ying Xue, Yi-Ming Liu and Xun Liao

    Chemistry Central Journal 2017 11:13

    Published on: 6 February 2017

  2. Research article

    Synthesis and biological evaluation of the new 1,3-dimethylxanthine derivatives with thiazolidine-4-one scaffold

    The xanthine structure has proved to be an important scaffold in the process of developing a wide variety of biologically active molecules such as bronchodilator, hypoglycemiant, anticancer and anti-inflammato...

    Sandra Constantin, Florentina Geanina Lupascu, Maria Apotrosoaei, Ioana Mirela Vasincu, Dan Lupascu, Frederic Buron, Sylvain Routier and Lenuta Profire

    Chemistry Central Journal 2017 11:12

    Published on: 1 February 2017

  3. Research article

    Cheminformatics studies to analyze the therapeutic potential of phytochemicals from Rhazya stricta

    Rhazya stricta is a unique medicinal plant source for many indole alkaloids, non-alkaloids, flavonoids, triterpenes and other unknown molecules with tremendous potential for therapeutic a...

    Abdullah Y. Obaid, Sreedhara Voleti, Roop Singh Bora, Nahid H. Hajrah, Abdulkader M. Shaikh Omer, Jamal S. M. Sabir and Kulvinder Singh Saini

    Chemistry Central Journal 2017 11:11

    Published on: 30 January 2017

  4. Research Article

    Design, synthesis, and biological evaluation of the novel glycyrrhetinic acid-cinnamoyl hybrids as anti-tumor agents

    Glycyrrhetinic acid (GA) derivatives had shown not only cytotoxicity but also could trigger apoptosis in various human cancer cell lines. Moreover, cinnamic acid (CA) and its phenolic analogues as potent antit...

    Wenbo Guo, Mengmeng Yan, Bing Xu, Fuhao Chu, Wei Wang, Chenze Zhang, Xiaohui Jia, Yaotian Han, Hongjun Xiang, Yuzhong Zhang, Penglong Wang and Haimin Lei

    Chemistry Central Journal 2016 10:78

    Published on: 1 December 2016

  5. Research article

    Platelet-12 lipoxygenase targeting via a newly synthesized curcumin derivative radiolabeled with technetium-99m

    One of the most popular techniques for cancer detection is the nuclear medicine technique. The present research focuses on Platelet-12-lipoxygenase (P-12-LOX) as a promising target for treating and radio-imagi...

    Reem Ibrahim Al-Wabli, Tamer Mostafa Mohamed Hafez Sakr, Mohammed Abdou Khedr, Adly Abdallah Selim, Mohamed Abd El-Motaleb Abd El-Rahman and Wafaa Abdou Zaghary

    Chemistry Central Journal 2016 10:73

    Published on: 28 November 2016

  6. Research article

    Synthesis of acyl oleanolic acid-uracil conjugates and their anti-tumor activity

    Oleanolic acid, which can be isolated from many foods and medicinal plants, has been reported to possess diverse biological activities. It has been found that the acylation of the hydroxyl groups of the A-ring...

    Wei-bin Mo, Chun-hua Su, Jia-yan Huang, Jun Liu, Zhen-feng Chen and Ke-guang Cheng

    Chemistry Central Journal 2016 10:69

    Published on: 21 November 2016

  7. Research article

    Further structure–activity relationships study of substituted dithiolethiones as glutathione-inducing neuroprotective agents

    Parkinson’s disease is a neurodegenerative disorder associated with oxidative stress and glutathione depletion. The induction of cellular glutathione levels by exogenous molecules is a promising neuroprotectiv...

    Dennis A. Brown, Swati Betharia, Jui-Hung Yen, Ping-Chang Kuo and Hitesh Mistry

    Chemistry Central Journal 2016 10:64

    Published on: 19 October 2016

  8. Research article

    Sol–gel encapsulation of Au nanoparticles in hybrid silica improves gold oxidation catalysis

    The introduction of an heterogeneously catalyzed gold-based alcohol oxidation process of broad applicability using a clean primary oxidant would be highly desirable. Gold is non toxic and carbonyl and carboxyl...

    Rosaria Ciriminna, Valerica Pandarus, Riccardo Delisi, Antonino Scurria, Maria Pia Casaletto, Francesco Giordano, François Béland and Mario Pagliaro

    Chemistry Central Journal 2016 10:61

    Published on: 13 October 2016

  9. Research Article

    Two new pterocarpans and a new pyrone derivative with cytotoxic activities from Ptycholobium contortum (N.E.Br.) Brummitt (Leguminosae): revised NMR assignment of mundulea lactone

    Ptycholobium is a genus related to Tephrosia which comprises only three species. Compared to Tephrosia, which has been phytochemically and pharmacologically studied, Ptycholobium speci...

    Dominique Ngnintedo, Ghislain W. Fotso, Victor Kuete, Frederic Nana, Louis P. Sandjo, Oğuzhan Karaosmanoğlu, Hülya Sivas, Felix Keumedjio, Gilbert Kirsch, Bonaventure T. Ngadjui and Kerstin Andrae-Marobela

    Chemistry Central Journal 2016 10:58

    Published on: 5 October 2016

  10. Research article

    4-aroylpiperidines and 4-(α-hydroxyphenyl)piperidines as selective sigma-1 receptor ligands: synthesis, preliminary pharmacological evaluation and computational studies

    Sigma (σ) receptors are membrane-bound proteins characterised by an unusual promiscuous ability to bind a wide variety of drugs and their high affinity for typical neuroleptic drugs, such as haloperidol, and t...

    Hermia N. Ikome, Fidele Ntie-Kang, Moses N. Ngemenya, Zhude Tu, Robert H. Mach and Simon M. N. Efange

    Chemistry Central Journal 2016 10:53

    Published on: 23 August 2016

  11. Research Article

    Polyphenolic glycosides isolated from Pogostemon cablin (Blanco) Benth. as novel influenza neuraminidase inhibitors

    Influenza is historically an ancient disease that causes annual epidemics and, at irregular intervals, pandemics. At present, the first-line drugs (oseltamivir and zanamivir) don’t seem to be optimistic due to...

    Fang Liu, Wei Cao, Chao Deng, Zhaoquan Wu, Guangyao Zeng and Yingjun Zhou

    Chemistry Central Journal 2016 10:51

    Published on: 10 August 2016

  12. Research article

    Microwave assisted synthesis, antifungal activity, DFT and SAR study of 1,2,4-triazolo[4,3-a]pyridine derivatives containing hydrazone moieties

    The increasing prevalence of multi-drug resistant fungal infections has encouraged the search for new antifungal agents. Hydrazone derivatives always exhibited diversity activities, including antifungal, anti-...

    Jin-Xia Mu, Yan-Xia Shi, Hong-Ke Wu, Zhao-Hui Sun, Ming-Yan Yang, Xing-Hai Liu and Bao-Ju Li

    Chemistry Central Journal 2016 10:50

    Published on: 4 August 2016

  13. Research article

    Anti-cholinesterases and memory improving effects of Vietnamese Xylia xylocarpa

    Alzheimer’s disease (AD) is the most common cause of dementia among the elderly and is characterized by loss of memory and other cognitive functions. An increase in AChE (a key enzyme in the cholinergic nervou...

    Linh My Thi Lam, Mai Thanh Thi Nguyen, Hai Xuan Nguyen, Phu Hoang Dang, Nhan Trung Nguyen, Hung Manh Tran, Hoa Thi Nguyen, Nui Minh Nguyen, Byung Sun Min, Jeong Ah Kim, Jae Sue Choi and Mao Van Can

    Chemistry Central Journal 2016 10:48

    Published on: 3 August 2016

  14. Research article

    A promising antitumor activity of evodiamine incorporated in hydroxypropyl-β-cyclodextrin: pro-apoptotic activity in human hepatoma HepG2 cells

    Evodiamine has gained wide interests recently because of its antitumor activities. However, a superior bioavailability is required to achieve better efficacy due to its poor water solubility. The aim of this s...

    Chao Qiu, Li-Na Gao, Kuo Yan, Yuan-Lu Cui and Ye Zhang

    Chemistry Central Journal 2016 10:46

    Published on: 25 July 2016

  15. Research article

    α-Glucosidase inhibitors from the bark of Mangifera mekongensis

    Mangifera mekongensis (Anacardiaceae) is cultivated for its edible fruit and has been used in traditional Vietnamese medicine for its anti-aging properties and for treating diabetes, v...

    Hai Xuan Nguyen, Tri Cong Le, Truong Nhat Van Do, Tho Huu Le, Nhan Trung Nguyen and Mai Thanh Thi Nguyen

    Chemistry Central Journal 2016 10:45

    Published on: 21 July 2016

  16. Research Article

    3-D structural interactions and quantitative structural toxicity studies of tyrosine derivatives intended for safe potent inflammation treatment

    Drugs that inhibit cyclooxygenase-2 (COX-2) while sparing cyclooxygenase-1 (COX-1) represent a new attractive therapeutic development and offer new perspective for further use of COX-2 inhibitors. Intention of...

    Ayarivan Puratchikody, Dharmaraj Sriram, Appavoo Umamaheswari and Navabshan Irfan

    Chemistry Central Journal 2016 10:24

    Published on: 30 April 2016

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