Organic and Medicinal Chemistry

This section publishes articles in all areas of organic chemistry and medicinal chemistry including organic synthesis, bioorganic chemistry, physical organic chemistry, stereochemistry, structure-activity relationships, synthetic methods, organometallic chemistry, supramolecular chemistry, and natural product chemistry.

Section Editors: Vassya Bankova, Tony James, Simon Lewis, Matthew Todd, Bimal Banik

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  1. Research article

    Synthesis and biological activity of myricetin derivatives containing 1,3,4-thiadiazole scaffold

    Myricetin and 1,3,4-thiadiazole derivatives were reported to exhibit favorable antiviral and antibacterial activities. Aiming to discover novel myricetin analogues with potent activities, a series of novel myr...

    Xinmin Zhong, Xiaobin Wang, Lijuan Chen, Xianghui Ruan, Qin Li, Juping Zhang, Zhuo Chen and Wei Xue

    Chemistry Central Journal 2017 11:106

    Published on: 17 October 2017

  2. Research article

    A facile access and evaluation of some novel thiazole and 1,3,4-thiadiazole derivatives incorporating thiazole moiety as potent anticancer agents

    Many heterocyclic compounds containing thiazole or 1,3,4-thiadiazole ring in their skeletons have been reported to possess various pharmacological activities especially anticancer activities.

    Sobhi M. Gomha, Mohamad R. Abdelaziz, Nabila A. Kheder, Hassan M. Abdel-aziz, Seham Alterary and Yahia N. Mabkhot

    Chemistry Central Journal 2017 11:105

    Published on: 16 October 2017

  3. Research Article

    Isolation, purification, structural analysis and coagulatory activity of water-soluble polysaccharides from Ligustrum lucidum Ait flowers

    In this study, Ligustrum lucidum flowers as raw material, the extraction, isolation and coagulatory activity of polysaccharides were carried out for the first time. The crude polysaccharide was obtained by hot wa...

    Zhenhua Yin, Wei Zhang, Juanjuan Zhang and Wenyi Kang

    Chemistry Central Journal 2017 11:98

    Published on: 4 October 2017

  4. Research article

    Synthesis and biological evaluation of tricyclic matrinic derivatives as a class of novel anti-HCV agents

    12N-benzyl matrinic acid analogues had been identified to be a novel scaffold of anti-HCV agents with a specific mechanism, and the representative compound 1 demonstrated a moderate anti-HCV activity. The intensi...

    Sheng Tang, Zong-Gen Peng, Ying-Hong Li, Xin Zhang, Tian-Yun Fan, Jian-Dong Jiang, Yan-Xiang Wang and Dan-Qing Song

    Chemistry Central Journal 2017 11:94

    Published on: 29 September 2017

  5. Research article

    The development of an effective synthetic route of lesinurad (RDEA594)

    Lesinurad is a novel selective uric acid salt transport protein 1 (URAT1) inhibitor which is approved in the USA for the treatment of gout. However, there are some shortcomings among the reported synthetic rou...

    Qing Meng, Tong Zhao, Dongwei Kang, Boshi Huang, Peng Zhan and Xinyong Liu

    Chemistry Central Journal 2017 11:86

    Published on: 5 September 2017

  6. Research article

    Synthesis, characterization, anti-ulcer action and molecular docking evaluation of novel benzimidazole-pyrazole hybrids

    A series of six novel benzimidazole-pyrazole hybrid molecules was synthesized and characterized using elemental analysis (CHN) and spectroscopic methods (1HNMR, FT-IR). All the synthesized compounds were evaluate...

    Abida Noor, Neelum Gul Qazi, Humaira Nadeem, Arif-ullah Khan, Rehan Zafar Paracha, Fawad Ali and Adil Saeed

    Chemistry Central Journal 2017 11:85

    Published on: 2 September 2017

  7. Research article

    Two phenolic antioxidants in Suoyang enhance viability of •OH-damaged mesenchymal stem cells: comparison and mechanistic chemistry

    Suoyang originates from a psammophyte named Cynomorium songaricum Rupr and has been known as a phenolic-antioxidant-enriched traditional Chinese herbal medicine. The present study atte...

    Yulu Xie, Xican Li, Jieying Xu, Qian Jiang, Hong Xie, Jianfeng He and Dongfeng Chen

    Chemistry Central Journal 2017 11:84

    Published on: 25 August 2017

  8. Research article

    Comprehensive spectral identification of key intermediates to the final product of the chiral pool synthesis of radezolid

    Radezolid (RAD, 12), biaryl oxazolidinone, was synthesised with small modifications according to the methods described in the literature. The pharmacological activity is observed only for (S)-enantiomer, therefor...

    Katarzyna Michalska, Elżbieta Bednarek, Ewa Gruba, Kornelia Lewandowska, Mikołaj Mizera and Judyta Cielecka-Piontek

    Chemistry Central Journal 2017 11:82

    Published on: 9 August 2017

  9. Research article

    One-step multicomponent synthesis of chiral oxazolinyl-zinc complexes

    Typically, oxazolinyl metal complexes are synthesized in two steps, where the free ligand is prepared by the condensation reaction between a functionalized nitrile and an amino alcohol in the presence of a Lew...

    Mei Luo, Jing Cheng Zhang, Wen Min Pang and King Kuok Hii

    Chemistry Central Journal 2017 11:81

    Published on: 9 August 2017

    The Erratum to this article has been published in Chemistry Central Journal 2017 11:91

  10. Research article

    Bis-pyrimidine acetamides: design, synthesis and biological evaluation

    In the past few years, increased resistance of microorganisms towards antimicrobial agents become a serious health problem, so there is a need for the discovery of new antimicrobial agents. On the other hand, ...

    Sanjiv Kumar, Siong Meng Lim, Kalavathy Ramasamy, Mani Vasudevan, Syed Adnan Ali Shah and Balasubramanian Narasimhan

    Chemistry Central Journal 2017 11:80

    Published on: 8 August 2017

  11. Research article

    Antimicrobial activity of thiophene derivatives derived from ethyl (E)-5-(3-(dimethylamino)acryloyl)-4-methyl-2-(phenylamino)thiophene-3-carboxylate

    The thiophene nucleus has been recognized as an important entity in the synthesis of heterocyclic compounds with promising pharmacological characteristics.

    Yahia Nasser Mabkhot, Nahed Ahmed Kaal, Seham Alterary, Salem S. Al-Showiman, Thoraya A. Farghaly and Mohammad S. Mubarak

    Chemistry Central Journal 2017 11:75

    Published on: 3 August 2017

  12. Research article

    Regioselective semi-synthesis of 6-isomers of 5,8-O-dimethyl ether of shikonin derivatives via an ‘intramolecular ring-closing/ring-opening’ strategy as potent anticancer agents

    Synthesis of 6-isomer of 5,8-O-dimethyl ether of shikonin (13), a promising anticancer scaffold, always remains a huge challenge. Herein a key intermediate for 13, 2-(1-hydroxyl-4-methyl-3-pentenyl)-1,4,5,8-tetra...

    Li Zhou, Xu Zhang and Wen Zhou

    Chemistry Central Journal 2017 11:74

    Published on: 2 August 2017

  13. Research article

    Structural optimization and evaluation of novel 2-pyrrolidone-fused (2-oxoindolin-3-ylidene)methylpyrrole derivatives as potential VEGFR-2/PDGFRβ inhibitors

    Tumor angiogenesis, essential for tumor growth and metastasis, is tightly regulated by VEGF/VEGFR and PDGF/PDGFR pathways, and therefore blocking those pathways is a promising therapeutic target. Compared to s...

    Ting-Hsuan Yang, Chun-I Lee, Wen-Hsin Huang and An-Rong Lee

    Chemistry Central Journal 2017 11:72

    Published on: 1 August 2017

  14. Research article

    One pot synthesis, antimicrobial and antioxidant activities of fused uracils: pyrimidodiazepines, lumazines, triazolouracil and xanthines

    Uracil derivatives have a great attraction because they play an important role in pharmacological activities. Pyrimidodiazepines, lumazines, triazolopyrimidines and xanthines have significant wide spectrum act...

    Samar A. El-Kalyoubi, Eman A. Fayed and Ahmed S. Abdel-Razek

    Chemistry Central Journal 2017 11:66

    Published on: 19 July 2017

    The Erratum to this article has been published in Chemistry Central Journal 2017 11:69

  15. Methodology

    RD-Metabolizer: an integrated and reaction types extensive approach to predict metabolic sites and metabolites of drug-like molecules

    Experimental approaches for determining the metabolic properties of the drug candidates are usually expensive, time-consuming and labor intensive. There is a great deal of interest in developing computational ...

    Jiajia Meng, Shiliang Li, Xiaofeng Liu, Mingyue Zheng and Honglin Li

    Chemistry Central Journal 2017 11:65

    Published on: 18 July 2017

  16. Research article

    Synthesis of some new pyrazolo[1,5-a]pyrimidine, pyrazolo[5,1-c]triazine, 1,3,4-thiadiazole and pyridine derivatives containing 1,2,3-triazole moiety

    Pyrazolo[1,5-a]pyrimidines are purine analogues. They have beneficial properties as antimetabolites in purine biochemical reactions. This division compounds have attracted wide pharmaceutical interest because of ...

    Nadia A. Abdelriheem, Yasser H. Zaki and Abdou O. Abdelhamid

    Chemistry Central Journal 2017 11:53

    Published on: 12 June 2017

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