Organic and Medicinal Chemistry

This section publishes peer-reviewed open access articles in all areas of organic chemistry and medicinal chemistry including organic synthesis, bioorganic chemistry, physical organic chemistry, stereochemistry, structure-activity relationships, synthetic methods, organometallic chemistry, supramolecular chemistry, and natural product chemistry.

Section Editors: Vassya Bankova, Tony James, Simon Lewis, Matthew Todd, Bimal Banik


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  1. Research article

    Comprehensive spectral identification of key intermediates to the final product of the chiral pool synthesis of radezolid

    Radezolid (RAD, 12), biaryl oxazolidinone, was synthesised with small modifications according to the methods described in the literature. The pharmacological activity is observed only for (S)-enantiomer, therefor...

    Katarzyna Michalska, Elżbieta Bednarek, Ewa Gruba, Kornelia Lewandowska, Mikołaj Mizera and Judyta Cielecka-Piontek

    Chemistry Central Journal 2017 11:82

    Published on: 9 August 2017

  2. Research article

    One-step multicomponent synthesis of chiral oxazolinyl-zinc complexes

    Typically, oxazolinyl metal complexes are synthesized in two steps, where the free ligand is prepared by the condensation reaction between a functionalized nitrile and an amino alcohol in the presence of a Lew...

    Mei Luo, Jing Cheng Zhang, Wen Min Pang and King Kuok Hii

    Chemistry Central Journal 2017 11:81

    Published on: 9 August 2017

  3. Research article

    Bis-pyrimidine acetamides: design, synthesis and biological evaluation

    In the past few years, increased resistance of microorganisms towards antimicrobial agents become a serious health problem, so there is a need for the discovery of new antimicrobial agents. On the other hand, ...

    Sanjiv Kumar, Siong Meng Lim, Kalavathy Ramasamy, Mani Vasudevan, Syed Adnan Ali Shah and Balasubramanian Narasimhan

    Chemistry Central Journal 2017 11:80

    Published on: 8 August 2017

  4. Research article

    Antimicrobial activity of thiophene derivatives derived from ethyl (E)-5-(3-(dimethylamino)acryloyl)-4-methyl-2-(phenylamino)thiophene-3-carboxylate

    The thiophene nucleus has been recognized as an important entity in the synthesis of heterocyclic compounds with promising pharmacological characteristics.

    Yahia Nasser Mabkhot, Nahed Ahmed Kaal, Seham Alterary, Salem S. Al-Showiman, Thoraya A. Farghaly and Mohammad S. Mubarak

    Chemistry Central Journal 2017 11:75

    Published on: 3 August 2017

  5. Research article

    Regioselective semi-synthesis of 6-isomers of 5,8-O-dimethyl ether of shikonin derivatives via an ‘intramolecular ring-closing/ring-opening’ strategy as potent anticancer agents

    Synthesis of 6-isomer of 5,8-O-dimethyl ether of shikonin (13), a promising anticancer scaffold, always remains a huge challenge. Herein a key intermediate for 13, 2-(1-hydroxyl-4-methyl-3-pentenyl)-1,4,5,8-tetra...

    Li Zhou, Xu Zhang and Wen Zhou

    Chemistry Central Journal 2017 11:74

    Published on: 2 August 2017

  6. Research article

    Structural optimization and evaluation of novel 2-pyrrolidone-fused (2-oxoindolin-3-ylidene)methylpyrrole derivatives as potential VEGFR-2/PDGFRβ inhibitors

    Tumor angiogenesis, essential for tumor growth and metastasis, is tightly regulated by VEGF/VEGFR and PDGF/PDGFR pathways, and therefore blocking those pathways is a promising therapeutic target. Compared to s...

    Ting-Hsuan Yang, Chun-I Lee, Wen-Hsin Huang and An-Rong Lee

    Chemistry Central Journal 2017 11:72

    Published on: 1 August 2017

  7. Research article

    One pot synthesis, antimicrobial and antioxidant activities of fused uracils: pyrimidodiazepines, lumazines, triazolouracil and xanthines

    Uracil derivatives have a great attraction because they play an important role in pharmacological activities. Pyrimidodiazepines, lumazines, triazolopyrimidines and xanthines have significant wide spectrum act...

    Samar A. El-Kalyoubi, Eman A. Fayed and Ahmed S. Abdel-Razek

    Chemistry Central Journal 2017 11:66

    Published on: 19 July 2017

    The Erratum to this article has been published in Chemistry Central Journal 2017 11:69

  8. Methodology

    RD-Metabolizer: an integrated and reaction types extensive approach to predict metabolic sites and metabolites of drug-like molecules

    Experimental approaches for determining the metabolic properties of the drug candidates are usually expensive, time-consuming and labor intensive. There is a great deal of interest in developing computational ...

    Jiajia Meng, Shiliang Li, Xiaofeng Liu, Mingyue Zheng and Honglin Li

    Chemistry Central Journal 2017 11:65

    Published on: 18 July 2017

  9. Research article

    Synthesis of some new pyrazolo[1,5-a]pyrimidine, pyrazolo[5,1-c]triazine, 1,3,4-thiadiazole and pyridine derivatives containing 1,2,3-triazole moiety

    Pyrazolo[1,5-a]pyrimidines are purine analogues. They have beneficial properties as antimetabolites in purine biochemical reactions. This division compounds have attracted wide pharmaceutical interest because of ...

    Nadia A. Abdelriheem, Yasser H. Zaki and Abdou O. Abdelhamid

    Chemistry Central Journal 2017 11:53

    Published on: 12 June 2017

  10. Research article

    Synthesis, characterization, X-ray structure, computational studies, and bioassay of novel compounds combining thiophene and benzimidazole or 1,2,4-triazole moieties

    Due to their interesting and versatile biological activity, thiophene-containing compounds have attracted the attention of both chemists and medicinal chemists. Some of these compounds have anticancer, antibac...

    Yahia N. Mabkhot, Salim S. Al-Showiman, Saied M. Soliman, Hazem A. Ghabbour, Murad A. AlDamen and Mohammad S. Mubarak

    Chemistry Central Journal 2017 11:51

    Published on: 9 June 2017

  11. Research article

    Synthesis and insecticidal activity of diacylhydrazine derivatives containing a 3-bromo-1-(3-chloropyridin-2-yl)-1H-pyrazole scaffold

    The diacylhydrazine derivatives have attracted considerable attention in recently years due to their simple structure, low toxicity, and high insecticidal selectivity. As well as 3-bromo-1-(3-chloropyridin-2-y...

    Yanyan Wang, Fangzhou Xu, Gang Yu, Jun Shi, Chuanhui Li, A’li Dai, Zhiqian Liu, Jiahong Xu, Fenghua Wang and Jian Wu

    Chemistry Central Journal 2017 11:50

    Published on: 5 June 2017

  12. Research article

    Synthesis, docking study and biological evaluation of some new thiourea derivatives bearing benzenesulfonamide moiety

    A series of novel N-(2, 6-dimethoxypyrimidin-4-yl)-4-(3-(aryl)thioureido) benzenesulfonamides 3at was synthesized by the addition of N-(2,6-dimethoxypyrimidin-4-yl)-4-isothiocyanatobenzenesulfonamide 2 to the ap...

    Mostafa M. Ghorab, Mohamed S. A. El-Gaby, Aiten M. Soliman, Mansour S. Alsaid, Marwa M. Abdel-Aziz and Mahmoud M. Elaasser

    Chemistry Central Journal 2017 11:42

    Published on: 19 May 2017

  13. Research article

    QSAR studies on PIM1 and PIM2 inhibitors using statistical methods: a rustic strategy to screen for 5-(1H-indol-5-yl)-1,3,4-thiadiazol analogues and predict their PIM inhibitory activity

    Quantitative structure activity relationship was carried out to study a series of PIM1 and PIM2 inhibitors. The present study was performed on twenty-five substituted 5-(1H-indol-5-yl)-1,3,4-thiadiazols as PIM...

    Adnane Aouidate, Adib Ghaleb, Mounir Ghamali, Samir Chtita, M’barek Choukrad, Abdelouahid Sbai, Mohammed Bouachrine and Tahar Lakhlifi

    Chemistry Central Journal 2017 11:41

    Published on: 19 May 2017

  14. Research article

    Synthesis, characterization and evaluation of 1,3,5-triazine aminobenzoic acid derivatives for their antimicrobial activity

    Replacement of chloride ions in cyanuric chloride give several variants of 1,3,5-triazine derivatives which were investigated as biologically active small molecules. These compounds exhibit antimalarial, antim...

    Khadijah M. Al-Zaydi, Hosam H. Khalil, Ayman El-Faham and Sherine N. Khattab

    Chemistry Central Journal 2017 11:39

    Published on: 10 May 2017

  15. Research article

    Antimicrobial and anticancer activity of some novel fluorinated thiourea derivatives carrying sulfonamide moieties: synthesis, biological evaluation and molecular docking

    Various thiourea derivatives have been used as starting materials for compounds with better biological activities. Molecular modeling tools are used to explore their mechanism of action.

    Mostafa M. Ghorab, Mansour S. Alsaid, Mohamed S. A. El-Gaby, Mahmoud M. Elaasser and Yassin M. Nissan

    Chemistry Central Journal 2017 11:32

    Published on: 7 April 2017

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