Biological Chemistry

This section publishes peer-reviewed open access articles in all areas of biologically- and medically-related chemistry including biochemistry, chemical biology, biotechnology, biomacromolecules, medicinal chemistry, carbohydrate chemistry, and toxicology.

Section Editors: Yasuhiro Nishiyama, Chris Swain and Paul Wrede

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  1. Research Article

    Mutagenicity, cytotoxic and antioxidant activities of Ricinus communis different parts

    Ricinus communis (castor plant) is a potent medicinal plant, which is commonly used in the treatment of various ailments. The present study was conducted to appraise the cytotoxicity and mutagenicity of R. commun...

    Mazhar Abbas, Abid Ali, Muhammad Arshad, Asia Atta, Zahed Mehmood, Imtiaz Mahmood Tahir and Munawar Iqbal

    Chemistry Central Journal 2018 12:3

    Published on: 19 January 2018

  2. Research article

    Optimization of phenolics and flavonoids extraction conditions of Curcuma Zedoaria leaves using response surface methodology

    This study focused on maximizing the extraction yield of total phenolics and flavonoids from Curcuma Zedoaria leaves as a function of time (80–120 min), temperature (60–80 °C) and ethanol concentration (70–90 v/v...

    Nur Fauwizah Azahar, Siti Salwa Abd Gani and Nor Fadzillah Mohd Mokhtar

    Chemistry Central Journal 2017 11:96

    Published on: 2 October 2017

  3. Research article

    Ultra-high resolution X-ray structures of two forms of human recombinant insulin at 100 K

    The crystal structure of a commercially available form of human recombinant (HR) insulin, Insugen (I), used in the treatment of diabetes has been determined to 0.92 Å resolution using low temperature, 100 K, s...

    David R. Lisgarten, Rex A. Palmer, Carina M. C. Lobley, Claire E. Naylor, Babur Z. Chowdhry, Zakieh I. Al-Kurdi, Adnan A. Badwan, Brendan J. Howlin, Nicholas C. J. Gibbons, José W. Saldanha, John N. Lisgarten and Ajit K. Basak

    Chemistry Central Journal 2017 11:73

    Published on: 1 August 2017

  4. Research article

    Optimization of enzymatic esterification of dihydrocaffeic acid with hexanol in ionic liquid using response surface methodology

    Developing an efficient lipophilization reaction system for phenolic derivatives could enhance their applications in food processing. Low solubility of phenolic acids reduces the efficiency of phenolic derivat...

    Somayeh Gholivand, Ola Lasekan, Chin Ping Tan, Faridah Abas and Leong Sze Wei

    Chemistry Central Journal 2017 11:44

    Published on: 26 May 2017

  5. Preliminary communication

    Highlighting mass spectrometric fragmentation differences and similarities between hydroxycinnamoyl-quinic acids and hydroxycinnamoyl-isocitric acids

    Plants contain a myriad of metabolites which exhibit diverse biological activities. However, in-depth analyses of these natural products with current analytical platforms remains an undisputed challenge due to...

    Keabetswe Masike, Msizi I. Mhlongo, Shonisani P. Mudau, Ofentse Nobela, Efficient N. Ncube, Fidele Tugizimana, Mosotho J. George and Ntakadzeni E. Madala

    Chemistry Central Journal 2017 11:29

    Published on: 4 April 2017

  6. Research article

    The effect of carbamic acid, (1,2,3-thiadiazole-4-ylcarbonyl)-hexyl ester on Peronophythora litchii infection, quality and physiology of postharvest litchi fruits

    Litchi (Litchi chinensis Sonn.) is a subtropical fruit with attractive characteristic of white to creamy semitranslucent flesh and red color in pericap, but it was easily subjected to the infection of Peronophyth...

    Hai Liu, Guoxing Jing, Yueming Jiang, Fuying Luo and Zaifeng Li

    Chemistry Central Journal 2017 11:14

    Published on: 6 February 2017

  7. Research Article

    Enhanced antibacterial activity of TiO2 nanoparticle surface modified with Garcinia zeylanica extract

    The antibacterial activity of 21 nm TiO2 nanoparticles (NPs) and particles modified with Garcinia zeylanica (G. zeylanica) against Methicillin resistant Staphylococcus aureus was investigated in the presence and ...

    U. L. N. H. Senarathna, S. S. N. Fernando, T. D. C. P. Gunasekara, M. M. Weerasekera, H. G. S. P. Hewageegana, N. D. H. Arachchi, H. D. Siriwardena and P. M. Jayaweera

    Chemistry Central Journal 2017 11:7

    Published on: 12 January 2017

  8. Research article

    HPLC estimation of iothalamate to measure glomerular filtration rate in humans

    Glomerular filtration rate (GFR) is usually determined by estimation of iothalamate (IOT) clearance. We have developed and validated an accurate and robust method for the analysis of IOT in human plasma and ur...

    Iltaf Shah, James Barker, Declan P. Naughton, Stephen J. Barton and Syed Salman Ashraf

    Chemistry Central Journal 2016 10:80

    Published on: 12 December 2016

  9. Research Article

    Preparation and characterization of a highly stable phenoxazinone synthase nanogel

    Phenoxazinone synthase (PHS) is a laccase-like multicopper oxidase originating from Streptomyces with great industrial application potential. In this paper, we prepared the PHS nanogel retaining 82 % of its initi...

    Honghua Jia, Zhen Gao, Yingying Ma, Chao Zhong, Chunming Wang, Hua Zhou and Ping Wei

    Chemistry Central Journal 2016 10:34

    Published on: 28 May 2016

  10. Methodology

    Freeze-drying: an alternative method for the analysis of volatile organic compounds in the headspace of urine samples using solid phase micro-extraction coupled to gas chromatography - mass spectrometry

    Volatile organic compounds (VOCs) can be intermediates of metabolic pathways and their levels in biological samples may provide a better understanding about diseases in addition to potential methods for diagno...

    Raphael B. M. Aggio, Arno Mayor, Séamus Coyle, Sophie Reade, Tanzeela Khalid, Norman M. Ratcliffe and Chris S. J. Probert

    Chemistry Central Journal 2016 10:9

    Published on: 1 March 2016

  11. Research article

    Analyses of chlorogenic acids and related cinnamic acid derivatives from Nicotiana tabacumtissues with the aid of UPLC-QTOF-MS/MS based on the in-source collision-induced dissociation method

    Chlorogenic acids (CGAs) are a class of phytochemicals that are formed as esters between different derivatives of cinnamic acid and quinic acid molecules. In plants, accumulation of these compounds has been li...

    Efficient N Ncube, Msizi I Mhlongo, Lizelle A Piater, Paul A Steenkamp, Ian A Dubery and Ntakadzeni E Madala

    Chemistry Central Journal 2014 8:66

    Published on: 19 November 2014

  12. Research article

    Cytotoxic Benzophenanthridine and Furoquinoline Alkaloids from Zanthoxylum buesgenii(Rutaceae)

    Zanthoxylum buesgenii is a shrub used in Sierra Leone as remedy to cure venereal diseases, arthritis, and rheumatism whereas leaves and barks are employed to treat leprosy and to relieve pain. In South West Regio...

    Louis P Sandjo, Victor Kuete, Rodrigue S Tchangna, Thomas Efferth and Bonaventure T Ngadjui

    Chemistry Central Journal 2014 8:61

    Published on: 21 October 2014

  13. Erratum

    Erratum: General peroxidase activity of a parallel G-quadruplex-hemin DNAzyme formed by Pu39WT - a mixed G-quadruplex forming sequence in the Bcl-2 P1 promoter

    This is a correction to the following paper: General peroxidase activity of a parallel G-quadruplex-hemin DNAzyme formed by Pu39WT - a mixed G-quadruplex forming sequence in the Bcl-2 P1 promoter, Bo Liu, Da L...

    Bo Liu, Hong Shang and Da Li

    Chemistry Central Journal 2014 8:57

    Published on: 30 September 2014

    The original article was published in Chemistry Central Journal 2014 8:43

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