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  1. Research article

    Optimization of enzymatic esterification of dihydrocaffeic acid with hexanol in ionic liquid using response surface methodology

    Developing an efficient lipophilization reaction system for phenolic derivatives could enhance their applications in food processing. Low solubility of phenolic acids reduces the efficiency of phenolic derivat...

    Somayeh Gholivand, Ola Lasekan, Chin Ping Tan, Faridah Abas and Leong Sze Wei

    Chemistry Central Journal 2017 11:44

    Published on: 26 May 2017

  2. Research article

    Different applications of isosbestic points, normalized spectra and dual wavelength as powerful tools for resolution of multicomponent mixtures with severely overlapping spectra

    Analysis of complex mixture containing three or more components represented a challenge for analysts. New smart spectrophotometric methods have been recently evolved with no limitation. A study of different no...

    Ekram H. Mohamed, Hayam M. Lotfy, Maha A. Hegazy and Shereen Mowaka

    Chemistry Central Journal 2017 11:43

    Published on: 25 May 2017

  3. Research article

    QSAR studies on PIM1 and PIM2 inhibitors using statistical methods: a rustic strategy to screen for 5-(1H-indol-5-yl)-1,3,4-thiadiazol analogues and predict their PIM inhibitory activity

    Quantitative structure activity relationship was carried out to study a series of PIM1 and PIM2 inhibitors. The present study was performed on twenty-five substituted 5-(1H-indol-5-yl)-1,3,4-thiadiazols as PIM...

    Adnane Aouidate, Adib Ghaleb, Mounir Ghamali, Samir Chtita, M’barek Choukrad, Abdelouahid Sbai, Mohammed Bouachrine and Tahar Lakhlifi

    Chemistry Central Journal 2017 11:41

    Published on: 19 May 2017

  4. Research article

    Synthesis, docking study and biological evaluation of some new thiourea derivatives bearing benzenesulfonamide moiety

    A series of novel N-(2, 6-dimethoxypyrimidin-4-yl)-4-(3-(aryl)thioureido) benzenesulfonamides 3at was synthesized by the addition of N-(2,6-dimethoxypyrimidin-4-yl)-4-isothiocyanatobenzenesulfonamide 2 to the ap...

    Mostafa M. Ghorab, Mohamed S. A. El-Gaby, Aiten M. Soliman, Mansour S. Alsaid, Marwa M. Abdel-Aziz and Mahmoud M. Elaasser

    Chemistry Central Journal 2017 11:42

    Published on: 19 May 2017

  5. Research article

    Synthesis, characterization and evaluation of 1,3,5-triazine aminobenzoic acid derivatives for their antimicrobial activity

    Replacement of chloride ions in cyanuric chloride give several variants of 1,3,5-triazine derivatives which were investigated as biologically active small molecules. These compounds exhibit antimalarial, antim...

    Khadijah M. Al-Zaydi, Hosam H. Khalil, Ayman El-Faham and Sherine N. Khattab

    Chemistry Central Journal 2017 11:39

    Published on: 10 May 2017

  6. Research article

    Synthesis, crystallographic, spectroscopic studies and biological activity of new cobalt(II) complexes with bioactive mixed sulindac and nitrogen-donor ligands

    Four novel complexes [Co(H2O)4(sul)2] 1, [Co(2-ampy)2(sul)2] 2, [Co(H2O)2(1,10-phen) (sul)2] 3 and [Co(2,9-dimephen)(sul)2] 4 (sul = sulindac, 2-ampy = 2-amino pyridine, 1,10-phen = 1,10-phenanthroline and 2,9-di...

    Asia M. Shalash and Hijazi I. Abu Ali

    Chemistry Central Journal 2017 11:40

    Published on: 10 May 2017

  7. Research article

    Application of a strategy based on metabolomics guided promoting blood circulation bioactivity compounds screening of vinegar

    Rice vinegar (RV) and white vinegar (WV) as daily flavoring, have also used as accessory in traditional Chinese medicine processing. As we know, the promoting blood circulation efficiency could be enhanced whe...

    Zhangchi Ning, Zhenli Liu, Zhiqian Song, Chun Wang, Yuanyan Liu, Jiahe Gan, Xinling Ma and Aiping Lu

    Chemistry Central Journal 2017 11:38

    Published on: 8 May 2017

  8. Research article

    Rapid simultaneous determination of indacaterol maleate and glycopyrronium bromide in inhaler capsules using a validated stability-indicating monolithic LC method

    Chronic obstructive pulmonary disease (COPD) is a major cause of morbidity and mortality worldwide. A combination of indacaterol maleate with glycopyrronium bromide has recently been approved as a once-daily m...

    Sahar Zayed and Fathalla Belal

    Chemistry Central Journal 2017 11:36

    Published on: 4 May 2017

  9. Research article

    Natural product based composite for extraction of arsenic (III) from waste water

    Natural based composites of hydroxyapatite/Gum Arabic designed for removal of toxic metal arsenic (III) from waste water were synthesized and evaluated. Several composites with various compositions were prepar...

    N. Akartasse, E. Mejdoubi, B. Razzouki, K. Azzaoui, S. Jodeh, O. Hamed, M. Ramdani, A. Lamhamdi, M. Berrabah, I. Lahmass, W. Jodeh and S. El Hajjaji

    Chemistry Central Journal 2017 11:33

    Published on: 12 April 2017

  10. Research article

    Antimicrobial and anticancer activity of some novel fluorinated thiourea derivatives carrying sulfonamide moieties: synthesis, biological evaluation and molecular docking

    Various thiourea derivatives have been used as starting materials for compounds with better biological activities. Molecular modeling tools are used to explore their mechanism of action.

    Mostafa M. Ghorab, Mansour S. Alsaid, Mohamed S. A. El-Gaby, Mahmoud M. Elaasser and Yassin M. Nissan

    Chemistry Central Journal 2017 11:32

    Published on: 7 April 2017

  11. Preliminary communication

    Highlighting mass spectrometric fragmentation differences and similarities between hydroxycinnamoyl-quinic acids and hydroxycinnamoyl-isocitric acids

    Plants contain a myriad of metabolites which exhibit diverse biological activities. However, in-depth analyses of these natural products with current analytical platforms remains an undisputed challenge due to...

    Keabetswe Masike, Msizi I. Mhlongo, Shonisani P. Mudau, Ofentse Nobela, Efficient N. Ncube, Fidele Tugizimana, Mosotho J. George and Ntakadzeni E. Madala

    Chemistry Central Journal 2017 11:29

    Published on: 4 April 2017

  12. Research article

    Acid-modified clinoptilolite as a support for palladium–copper complexes catalyzing carbon monoxide oxidation with air oxygen

    Samples of natural clinoptilolite were modified by an acid–thermal method at nitric acid concentrations of 0.25, 0.5, 1.0, and 3.0 M and a contact time of 30 min. A series of catalysts, K2PdCl4–Cu(NO3)2–KBr/S (S ...

    Tatyana L. Rakitskaya, Tatyana A. Kiose, Kristina O. Golubchik, Alim A. Ennan and Vitalia Y. Volkova

    Chemistry Central Journal 2017 11:28

    Published on: 27 March 2017

  13. Research article

    Non-destructive determination of ethanol levels in fermented alcoholic beverages using Fourier transform mid-infrared spectroscopy

    Traditional fermented alcoholic beverages are indigenous to a particular area and are prepared by the local people using an age-old techniques and locally available raw materials. The main objective of this wo...

    Ayalew Debebe, Mesfin Redi-Abshiro and Bhagwan Singh Chandravanshi

    Chemistry Central Journal 2017 11:27

    Published on: 24 March 2017

  14. Research article

    Preparation of a ferulic acid–phospholipid complex to improve solubility, dissolution, and B16F10 cellular melanogenesis inhibition activity

    We aimed to enhance the solubility, dissolution properties, and skin-whitening ability of ferulic acid (FA) by preparing a ferulic acid–phospholipid complex (FA–PC). The properties and melanogenesis inhibition...

    Li Li, Yanhong Liu, Yan Xue, Jun Zhu, Xiaoyue Wang and Yinmao Dong

    Chemistry Central Journal 2017 11:26

    Published on: 22 March 2017

  15. Review

    Citric acid: emerging applications of key biotechnology industrial product

    Owing to new biotechnological production units mostly located in China, global supply of citric acid in the course of the last two decades rose from less than 0.5 to more than 2 million tonnes becoming the sin...

    Rosaria Ciriminna, Francesco Meneguzzo, Riccardo Delisi and Mario Pagliaro

    Chemistry Central Journal 2017 11:22

    Published on: 8 March 2017

  16. Research article

    Modeling and optimization of nanoemulsion containing Sorafenib for cancer treatment by response surface methodology

    The aim of this study is the development of nanoemulsions for intravenous administration of Sorafenib, which is a poorly soluble drug with no parenteral treatment. The formulation was prepared by a high energy...

    Zahra Izadiyan, Mahiran Basri, Hamid Reza Fard Masoumi, Roghayeh Abedi Karjiban, Norazlinaliza Salim and Kamyar Shameli

    Chemistry Central Journal 2017 11:21

    Published on: 2 March 2017

  17. Research article

    Synthesis and protective effect of new ligustrazine-vanillic acid derivatives against CoCl2-induced neurotoxicity in differentiated PC12 cells

    Ligustrazine-vanillic acid derivatives had been reported to exhibit promising neuroprotective activities. In our continuous effort to develop new ligustrazine derivatives with neuroprotective effects, we attem...

    Bing Xu, Xin Xu, Chenze Zhang, Yuzhong Zhang, GaoRong Wu, Mengmeng Yan, Menglu Jia, Tianxin Xie, Xiaohui Jia, Penglong Wang and Haimin Lei

    Chemistry Central Journal 2017 11:20

    Published on: 28 February 2017

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