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  1. Research article

    A traditional poly herbal medicine “Le Pana Guliya induces apoptosis in HepG2 and HeLa cells but not in CC1 cells: an in vitro assessment

    “Le Pana Guliya” (LPG) is a polyherbal formulation which is used to treat different types of cancers in traditional medicine. In this study we describe in vitro efficacy and mechanism of action of LPG on two c...

    Nekadage Don Amal Wageesha, Preethi Soysa, Keerthi Atthanayake, Muhammad Iqbal Choudhary and Mahinda Ekanayake

    Chemistry Central Journal 2017 11:2

    Published on: 3 January 2017

  2. Research article

    HPLC estimation of iothalamate to measure glomerular filtration rate in humans

    Glomerular filtration rate (GFR) is usually determined by estimation of iothalamate (IOT) clearance. We have developed and validated an accurate and robust method for the analysis of IOT in human plasma and ur...

    Iltaf Shah, James Barker, Declan P. Naughton, Stephen J. Barton and Syed Salman Ashraf

    Chemistry Central Journal 2016 10:80

    Published on: 12 December 2016

  3. Research article

    In vitro drug release characteristic and cytotoxic activity of silibinin-loaded single walled carbon nanotubes functionalized with biocompatible polymers

    In this paper, we demonstrate the preparation of silibinin-loaded carbon nanotubes (SWSB) with surface coating agents via non-covalent approach as an effective drug delivery system. The resulting surface-coate...

    Julia Meihua Tan, Govindarajan Karthivashan, Shafinaz Abd Gani, Sharida Fakurazi and Mohd Zobir Hussein

    Chemistry Central Journal 2016 10:81

    Published on: 12 December 2016

  4. Research article

    Application of dosimetry tools for the assessment of e-cigarette aerosol and cigarette smoke generated on two different in vitro exposure systems

    The diluted aerosols from a cigarette (3R4F) and an e-cigarette (Vype ePen) were compared in two commercially available in vitro exposure systems: the Borgwaldt RM20S and Vitrocell VC10. Dosimetry was assessed...

    Jason Adamson, David Thorne, Benjamin Zainuddin, Andrew Baxter, John McAughey and Marianna Gaça

    Chemistry Central Journal 2016 10:74

    Published on: 9 December 2016

  5. Research Article

    Design, synthesis, and biological evaluation of the novel glycyrrhetinic acid-cinnamoyl hybrids as anti-tumor agents

    Glycyrrhetinic acid (GA) derivatives had shown not only cytotoxicity but also could trigger apoptosis in various human cancer cell lines. Moreover, cinnamic acid (CA) and its phenolic analogues as potent antit...

    Wenbo Guo, Mengmeng Yan, Bing Xu, Fuhao Chu, Wei Wang, Chenze Zhang, Xiaohui Jia, Yaotian Han, Hongjun Xiang, Yuzhong Zhang, Penglong Wang and Haimin Lei

    Chemistry Central Journal 2016 10:78

    Published on: 1 December 2016

  6. Research Article

    Rapid micellar HPLC analysis of loratadine and its major metabolite desloratadine in nano-concentration range using monolithic column and fluorometric detection: application to pharmaceuticals and biological fluids

    Loratadine is a commonly used selective non-sedating antihistaminic drug. Desloratadine is the active metabolite of loratadine and, in addition, a potential impurity in loratadine bulk powder stated by the Uni...

    Fathalla Belal, Sawsan Abd El-Razeq, Mohamed El-Awady, Sahar Zayed and Sona Barghash

    Chemistry Central Journal 2016 10:79

    Published on: 1 December 2016

  7. Research Article

    Analysis of tilianin and acacetin in Agastache rugosa by high-performance liquid chromatography with ionic liquids-ultrasound based extraction

    Ionic liquid 1-butyl-3-methylimidazolium bromide-methanol-based ultrasonic-assisted extraction (ILUAE) was used to extract tilianin and acacetin from the aerial parts of Agastache rugose (A. rugose), and simultan...

    Jinfeng Wei, Pengran Cao, Jinmei Wang and Wenyi Kang

    Chemistry Central Journal 2016 10:76

    Published on: 29 November 2016

  8. Research article

    Platelet-12 lipoxygenase targeting via a newly synthesized curcumin derivative radiolabeled with technetium-99m

    One of the most popular techniques for cancer detection is the nuclear medicine technique. The present research focuses on Platelet-12-lipoxygenase (P-12-LOX) as a promising target for treating and radio-imagi...

    Reem Ibrahim Al-Wabli, Tamer Mostafa Mohamed Hafez Sakr, Mohammed Abdou Khedr, Adly Abdallah Selim, Mohamed Abd El-Motaleb Abd El-Rahman and Wafaa Abdou Zaghary

    Chemistry Central Journal 2016 10:73

    Published on: 28 November 2016

  9. Research article

    Synthesis of acyl oleanolic acid-uracil conjugates and their anti-tumor activity

    Oleanolic acid, which can be isolated from many foods and medicinal plants, has been reported to possess diverse biological activities. It has been found that the acylation of the hydroxyl groups of the A-ring...

    Wei-bin Mo, Chun-hua Su, Jia-yan Huang, Jun Liu, Zhen-feng Chen and Ke-guang Cheng

    Chemistry Central Journal 2016 10:69

    Published on: 21 November 2016

  10. Research article

    Hydrotalcite-quinolinate composites as catalysts in a coupling reaction

    Samples of layered double hydroxides were prepared by a sol–gel procedure. Quinolinate Al(C9H6NO)3 units were added during the synthesis, leading to composite quinolinate hydrotalcite-like compounds. The amount o...

    Eloisa Ríos, Magali Hernández, Ilich A. Ibarra, Ariel Guzmán and Enrique Lima

    Chemistry Central Journal 2016 10:68

    Published on: 31 October 2016

  11. Research article

    DFT and TD-DFT calculation of new thienopyrazine-based small molecules for organic solar cells

    Novel six organic donor-π-acceptor molecules (D-π-A) used for Bulk Heterojunction organic solar cells (BHJ), based on thienopyrazine were studied by density functional theory (DFT) and time-dependent DFT (TD-D...

    Mohamed Bourass, Adil Touimi Benjelloun, Mohammed Benzakour, Mohammed Mcharfi, Mohammed Hamidi, Si Mohamed Bouzzine and Mohammed Bouachrine

    Chemistry Central Journal 2016 10:67

    Published on: 27 October 2016

  12. Research article

    Investigation on the self-association of an inorganic coordination compound with biological activity (Casiopeína III-ia) in aqueous solution

    From studies using different experimental techniques employed to determine the presence of aggregates e.g. isothermal titration calorimetry, surface tension, electrical conductivity, UV–Vis spectrophotometry, ...

    Alejandro Marín-Medina, Juan Carlos García-Ramos, Lena Ruíz-Azuara and Ernesto Carrillo-Nava

    Chemistry Central Journal 2016 10:65

    Published on: 21 October 2016

  13. Research article

    Further structure–activity relationships study of substituted dithiolethiones as glutathione-inducing neuroprotective agents

    Parkinson’s disease is a neurodegenerative disorder associated with oxidative stress and glutathione depletion. The induction of cellular glutathione levels by exogenous molecules is a promising neuroprotectiv...

    Dennis A. Brown, Swati Betharia, Jui-Hung Yen, Ping-Chang Kuo and Hitesh Mistry

    Chemistry Central Journal 2016 10:64

    Published on: 19 October 2016

  14. Short report

    Quick assessment of the economic value of olive mill waste water

    Olive biophenols are emerging as a valued class of natural products finding practical application in the food, pharmaceutical, beverage, cosmetic and nutraceutical industries due to their powerful biological a...

    Riccardo Delisi, Filippo Saiano, Mario Pagliaro and Rosaria Ciriminna

    Chemistry Central Journal 2016 10:63

    Published on: 17 October 2016

  15. Research article

    The pharmacokinetics, bioavailability and excretion of bergapten after oral and intravenous administration in rats using high performance liquid chromatography with fluorescence detection

    A sensitive, specific, reproducible and optimized high performance liquid chromatography with fluorescence detection (HPLC-FLD) method for the determination of bergapten in rat plasma was established and appli...

    Xie-an Yu, John Teye Azietaku, Jin Li, Mingrui An, Jun He, Jia Hao, Jun Cao and Yan-xu Chang

    Chemistry Central Journal 2016 10:62

    Published on: 14 October 2016

  16. Research article

    Sol–gel encapsulation of Au nanoparticles in hybrid silica improves gold oxidation catalysis

    The introduction of an heterogeneously catalyzed gold-based alcohol oxidation process of broad applicability using a clean primary oxidant would be highly desirable. Gold is non toxic and carbonyl and carboxyl...

    Rosaria Ciriminna, Valerica Pandarus, Riccardo Delisi, Antonino Scurria, Maria Pia Casaletto, Francesco Giordano, François Béland and Mario Pagliaro

    Chemistry Central Journal 2016 10:61

    Published on: 13 October 2016

  17. Research article

    Kinetic modeling of nicotine in mainstream cigarette smoking

    The attempt to understand the kinetic behavior of nicotine in tobacco will provide a basis for unraveling its energetics in tobacco burning and the formation of free radicals considered harmful to the cigarett...

    Joshua Kibet, Caren Kurgat, Samuel Limo, Nicholas Rono and Josephate Bosire

    Chemistry Central Journal 2016 10:60

    Published on: 12 October 2016

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