Organic and Medicinal Chemistry

This section publishes peer-reviewed open access articles in all areas of organic chemistry and medicinal chemistry including organic synthesis, bioorganic chemistry, physical organic chemistry, stereochemistry, structure-activity relationships, synthetic methods, organometallic chemistry, supramolecular chemistry, and natural product chemistry.

Section Editors: Vassya Bankova, Tony James, Simon Lewis, Matthew Todd, Bimal Banik

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  1. Research article

    4-aroylpiperidines and 4-(α-hydroxyphenyl)piperidines as selective sigma-1 receptor ligands: synthesis, preliminary pharmacological evaluation and computational studies

    Sigma (σ) receptors are membrane-bound proteins characterised by an unusual promiscuous ability to bind a wide variety of drugs and their high affinity for typical neuroleptic drugs, such as haloperidol, and t...

    Hermia N. Ikome, Fidele Ntie-Kang, Moses N. Ngemenya, Zhude Tu, Robert H. Mach and Simon M. N. Efange

    Chemistry Central Journal 2016 10:53

    Published on: 23 August 2016

  2. Research Article

    Polyphenolic glycosides isolated from Pogostemon cablin (Blanco) Benth. as novel influenza neuraminidase inhibitors

    Influenza is historically an ancient disease that causes annual epidemics and, at irregular intervals, pandemics. At present, the first-line drugs (oseltamivir and zanamivir) don’t seem to be optimistic due to...

    Fang Liu, Wei Cao, Chao Deng, Zhaoquan Wu, Guangyao Zeng and Yingjun Zhou

    Chemistry Central Journal 2016 10:51

    Published on: 10 August 2016

  3. Research article

    Microwave assisted synthesis, antifungal activity, DFT and SAR study of 1,2,4-triazolo[4,3-a]pyridine derivatives containing hydrazone moieties

    The increasing prevalence of multi-drug resistant fungal infections has encouraged the search for new antifungal agents. Hydrazone derivatives always exhibited diversity activities, including antifungal, anti-...

    Jin-Xia Mu, Yan-Xia Shi, Hong-Ke Wu, Zhao-Hui Sun, Ming-Yan Yang, Xing-Hai Liu and Bao-Ju Li

    Chemistry Central Journal 2016 10:50

    Published on: 4 August 2016

  4. Research article

    Anti-cholinesterases and memory improving effects of Vietnamese Xylia xylocarpa

    Alzheimer’s disease (AD) is the most common cause of dementia among the elderly and is characterized by loss of memory and other cognitive functions. An increase in AChE (a key enzyme in the cholinergic nervou...

    Linh My Thi Lam, Mai Thanh Thi Nguyen, Hai Xuan Nguyen, Phu Hoang Dang, Nhan Trung Nguyen, Hung Manh Tran, Hoa Thi Nguyen, Nui Minh Nguyen, Byung Sun Min, Jeong Ah Kim, Jae Sue Choi and Mao Van Can

    Chemistry Central Journal 2016 10:48

    Published on: 3 August 2016

  5. Research article

    A promising antitumor activity of evodiamine incorporated in hydroxypropyl-β-cyclodextrin: pro-apoptotic activity in human hepatoma HepG2 cells

    Evodiamine has gained wide interests recently because of its antitumor activities. However, a superior bioavailability is required to achieve better efficacy due to its poor water solubility. The aim of this s...

    Chao Qiu, Li-Na Gao, Kuo Yan, Yuan-Lu Cui and Ye Zhang

    Chemistry Central Journal 2016 10:46

    Published on: 25 July 2016

  6. Research article

    α-Glucosidase inhibitors from the bark of Mangifera mekongensis

    Mangifera mekongensis (Anacardiaceae) is cultivated for its edible fruit and has been used in traditional Vietnamese medicine for its anti-aging properties and for treating diabetes, v...

    Hai Xuan Nguyen, Tri Cong Le, Truong Nhat Van Do, Tho Huu Le, Nhan Trung Nguyen and Mai Thanh Thi Nguyen

    Chemistry Central Journal 2016 10:45

    Published on: 21 July 2016

  7. Research Article

    3-D structural interactions and quantitative structural toxicity studies of tyrosine derivatives intended for safe potent inflammation treatment

    Drugs that inhibit cyclooxygenase-2 (COX-2) while sparing cyclooxygenase-1 (COX-1) represent a new attractive therapeutic development and offer new perspective for further use of COX-2 inhibitors. Intention of...

    Ayarivan Puratchikody, Dharmaraj Sriram, Appavoo Umamaheswari and Navabshan Irfan

    Chemistry Central Journal 2016 10:24

    Published on: 30 April 2016

  8. Research article

    Molecular docking study and antiviral evaluation of 2-thioxo-benzo[g]quinazolin-4(3H)-one derivatives

    The persistent appearance of viral strains that causes a resistant viral infection has led to continuous trials for the design and development of novel antiviral compounds. Benzoquinazoline compounds have been...

    Rashad Al-Salahi, Hatem A. Abuelizz, Hazem A. Ghabbour, Rabab El-Dib and Mohamed Marzouk

    Chemistry Central Journal 2016 10:21

    Published on: 19 April 2016

  9. Research Article

    Design, synthesis and anticancer activity of some novel thioureido-benzenesulfonamides incorporated biologically active moieties

    Many thiourea derivatives have exhibited biological activities including anticancer activity through several mechanisms. On the other hand, benzenesulfonamide derivatives have proven to be good anticancer agen...

    Mostafa M. Ghorab, Mansour S. Alsaid, Mohamed S. Al-Dosary, Yassin M. Nissan and Sabry M. Attia

    Chemistry Central Journal 2016 10:19

    Published on: 7 April 2016

  10. Research article

    Novel chloroquinoline derivatives incorporating biologically active benzenesulfonamide moiety: synthesis, cytotoxic activity and molecular docking

    Quinoline derivatives have diverse biological activities including anticancer activity. On the other hand, many sulfonamide derivatives exhibited good cytotoxic activity. Hybrids of both moieties may present n...

    Mostafa M. Ghorab, Mansour S. Alsaid, Mohammed S. Al-Dosari, Yassin M. Nissan and Abdullah A. Al-Mishari

    Chemistry Central Journal 2016 10:18

    Published on: 5 April 2016

  11. Research Article

    Regioselectivity of 1,3-dipolar cycloadditions and antimicrobial activity of isoxazoline, pyrrolo[3,4-d]isoxazole-4,6-diones, pyrazolo[3,4-d]pyridazines and pyrazolo[1,5-a]pyrimidines

    Isoxazoles exhibit interesting biological activities, and the 1,3-dipolar cycloaddition(13DC) reactions play an important role in both mechanistic and synthetic organic chemistry. Pyrazoles and annulated pyraz...

    Yasser Hassan Zaki, Abdelwahed Rashad Sayed and Shaaban A. Elroby

    Chemistry Central Journal 2016 10:17

    Published on: 1 April 2016

  12. Research article

    Synthesis and structural properties of 2-((10-alkyl-10H-phenothiazin-3-yl)methylene)malononitrile derivatives; a combined experimental and theoretical insight

    Donor acceptor moieties connected through π-conjugated bridges i.e. D-π-A, in order to facilitate the electron/charge transfer phenomenon, have wide range of applications. Many classes of organic compounds, su...

    Fatimah Ali Al-Zahrani, Muhammad Nadeem Arshad, Abdullah M. Asiri, Tariq Mahmood, Mazhar Amjad Gilani and Reda M. El-shishtawy

    Chemistry Central Journal 2016 10:13

    Published on: 15 March 2016

  13. Research Article

    Synthesis and biological evaluation of new 1,3-thiazolidine-4-one derivatives of nitro-l-arginine methyl ester

    l-Arginine is a semi-essential aminoacid with important role in regulation of physiological processes in humans. It serves as precursor for the synthesis of proteins and is also substr...

    Andreea-Teodora Pânzariu, Maria Apotrosoaei, Ioana Mirela Vasincu, Maria Drăgan, Sandra Constantin, Frédéric Buron, Sylvain Routier, Lenuta Profire and Cristina Tuchilus

    Chemistry Central Journal 2016 10:6

    Published on: 4 February 2016

  14. Research article

    Synthesis and antibacterial and antifungal activities of N-(tetra-O-acetyl-β-d-glucopyranosyl)thiosemicarbazones of substituted 4-formylsydnones

    Sydnone is a heterocycle that exhibits remarkable pharmacological activities, including antimicrobial, anti-inflammatory, analgesic, antipyretic and antioxidant activities. Thiosemicarbazones are of compounds ...

    Nguyen Dinh Thanh, Hoang Thanh Duc, Vu Thi Duyen, Phan Manh Tuong and Nguyen Van Quoc

    Chemistry Central Journal 2015 9:60

    Published on: 19 October 2015

  15. Research article

    Regioselective synthesis of 2-(bromomethyl)-5-aryl-thiophene derivatives viapalladium (0) catalyzed suzuki cross-coupling reactions: as antithrombotic and haemolytically active molecules

    It is seen that the regioselective functionalizations of halogenated heterocycles play an important role in the synthesis of several types of organic compounds. In this domain, the Suzuki-Miyaura reaction has ...

    Komal Rizwan, Muhammad Zubair, Nasir Rasool, Shaukat Ali, Ameer Fawad Zahoor, Usman Ali Rana, Salah Ud-Din Khan, Muhammad Shahid, Muhammad Zia-Ul-Haq and Hawa ZE Jaafar

    Chemistry Central Journal 2014 8:74

    Published on: 17 December 2014

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