Organic and Medicinal Chemistry

This section publishes peer-reviewed open access articles in all areas of organic chemistry and medicinal chemistry including organic synthesis, bioorganic chemistry, physical organic chemistry, stereochemistry, structure-activity relationships, synthetic methods, organometallic chemistry, supramolecular chemistry, and natural product chemistry.

Section Editors: Vassya Bankova, Tony James, Simon Lewis, Matthew Todd, Bimal Banik


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  1. Research article

    QSAR studies on PIM1 and PIM2 inhibitors using statistical methods: a rustic strategy to screen for 5-(1H-indol-5-yl)-1,3,4-thiadiazol analogues and predict their PIM inhibitory activity

    Quantitative structure activity relationship was carried out to study a series of PIM1 and PIM2 inhibitors. The present study was performed on twenty-five substituted 5-(1H-indol-5-yl)-1,3,4-thiadiazols as PIM...

    Adnane Aouidate, Adib Ghaleb, Mounir Ghamali, Samir Chtita, M’barek Choukrad, Abdelouahid Sbai, Mohammed Bouachrine and Tahar Lakhlifi

    Chemistry Central Journal 2017 11:41

    Published on: 19 May 2017

  2. Research article

    Synthesis, docking study and biological evaluation of some new thiourea derivatives bearing benzenesulfonamide moiety

    A series of novel N-(2, 6-dimethoxypyrimidin-4-yl)-4-(3-(aryl)thioureido) benzenesulfonamides 3at was synthesized by the addition of N-(2,6-dimethoxypyrimidin-4-yl)-4-isothiocyanatobenzenesulfonamide 2 to the ap...

    Mostafa M. Ghorab, Mohamed S. A. El-Gaby, Aiten M. Soliman, Mansour S. Alsaid, Marwa M. Abdel-Aziz and Mahmoud M. Elaasser

    Chemistry Central Journal 2017 11:42

    Published on: 19 May 2017

  3. Research article

    Synthesis, characterization and evaluation of 1,3,5-triazine aminobenzoic acid derivatives for their antimicrobial activity

    Replacement of chloride ions in cyanuric chloride give several variants of 1,3,5-triazine derivatives which were investigated as biologically active small molecules. These compounds exhibit antimalarial, antim...

    Khadijah M. Al-Zaydi, Hosam H. Khalil, Ayman El-Faham and Sherine N. Khattab

    Chemistry Central Journal 2017 11:39

    Published on: 10 May 2017

  4. Research article

    Antimicrobial and anticancer activity of some novel fluorinated thiourea derivatives carrying sulfonamide moieties: synthesis, biological evaluation and molecular docking

    Various thiourea derivatives have been used as starting materials for compounds with better biological activities. Molecular modeling tools are used to explore their mechanism of action.

    Mostafa M. Ghorab, Mansour S. Alsaid, Mohamed S. A. El-Gaby, Mahmoud M. Elaasser and Yassin M. Nissan

    Chemistry Central Journal 2017 11:32

    Published on: 7 April 2017

  5. Research article

    Modeling and optimization of nanoemulsion containing Sorafenib for cancer treatment by response surface methodology

    The aim of this study is the development of nanoemulsions for intravenous administration of Sorafenib, which is a poorly soluble drug with no parenteral treatment. The formulation was prepared by a high energy...

    Zahra Izadiyan, Mahiran Basri, Hamid Reza Fard Masoumi, Roghayeh Abedi Karjiban, Norazlinaliza Salim and Kamyar Shameli

    Chemistry Central Journal 2017 11:21

    Published on: 2 March 2017

  6. Research article

    Synthesis and protective effect of new ligustrazine-vanillic acid derivatives against CoCl2-induced neurotoxicity in differentiated PC12 cells

    Ligustrazine-vanillic acid derivatives had been reported to exhibit promising neuroprotective activities. In our continuous effort to develop new ligustrazine derivatives with neuroprotective effects, we attem...

    Bing Xu, Xin Xu, Chenze Zhang, Yuzhong Zhang, GaoRong Wu, Mengmeng Yan, Menglu Jia, Tianxin Xie, Xiaohui Jia, Penglong Wang and Haimin Lei

    Chemistry Central Journal 2017 11:20

    Published on: 28 February 2017

  7. Research article

    2-Benzyl-benzofurans from the tubers of Ophiopogon japonicus

    The overproduction of nitric oxide (NO) is known to involve in various inflammatory processes. A methanol extract of the tubers of Ophiopogon japonicus was found to strongly inhibit NO production. The present pap...

    Nguyen Hai Dang, Nguyen Dinh Chung, Ha Manh Tuan, Nguyen Van Thanh, Nguyen Tuan Hiep, Dongho Lee and Nguyen Tien Dat

    Chemistry Central Journal 2017 11:15

    Published on: 6 February 2017

  8. Research article

    Characterization of major metabolites of polymethoxylated flavonoids in Pericarpium Citri Reticulatae using liver microsomes immobilized on magnetic nanoparticles coupled with UPLC/MS–MS

    The peels of citrus fruits (Pericarpium Citri Reticulatae, PCR) have long been used in traditional Chinese medicines (TCMs). Polymethoxylated flavonoids (PMFs) were found to be the main components present in ...

    Jun Lei, Ying Xue, Yi-Ming Liu and Xun Liao

    Chemistry Central Journal 2017 11:13

    Published on: 6 February 2017

  9. Research article

    Synthesis and biological evaluation of the new 1,3-dimethylxanthine derivatives with thiazolidine-4-one scaffold

    The xanthine structure has proved to be an important scaffold in the process of developing a wide variety of biologically active molecules such as bronchodilator, hypoglycemiant, anticancer and anti-inflammato...

    Sandra Constantin, Florentina Geanina Lupascu, Maria Apotrosoaei, Ioana Mirela Vasincu, Dan Lupascu, Frederic Buron, Sylvain Routier and Lenuta Profire

    Chemistry Central Journal 2017 11:12

    Published on: 1 February 2017

  10. Research article

    Cheminformatics studies to analyze the therapeutic potential of phytochemicals from Rhazya stricta

    Rhazya stricta is a unique medicinal plant source for many indole alkaloids, non-alkaloids, flavonoids, triterpenes and other unknown molecules with tremendous potential for therapeutic a...

    Abdullah Y. Obaid, Sreedhara Voleti, Roop Singh Bora, Nahid H. Hajrah, Abdulkader M. Shaikh Omer, Jamal S. M. Sabir and Kulvinder Singh Saini

    Chemistry Central Journal 2017 11:11

    Published on: 30 January 2017

  11. Research Article

    Design, synthesis, and biological evaluation of the novel glycyrrhetinic acid-cinnamoyl hybrids as anti-tumor agents

    Glycyrrhetinic acid (GA) derivatives had shown not only cytotoxicity but also could trigger apoptosis in various human cancer cell lines. Moreover, cinnamic acid (CA) and its phenolic analogues as potent antit...

    Wenbo Guo, Mengmeng Yan, Bing Xu, Fuhao Chu, Wei Wang, Chenze Zhang, Xiaohui Jia, Yaotian Han, Hongjun Xiang, Yuzhong Zhang, Penglong Wang and Haimin Lei

    Chemistry Central Journal 2016 10:78

    Published on: 1 December 2016

  12. Research article

    Platelet-12 lipoxygenase targeting via a newly synthesized curcumin derivative radiolabeled with technetium-99m

    One of the most popular techniques for cancer detection is the nuclear medicine technique. The present research focuses on Platelet-12-lipoxygenase (P-12-LOX) as a promising target for treating and radio-imagi...

    Reem Ibrahim Al-Wabli, Tamer Mostafa Mohamed Hafez Sakr, Mohammed Abdou Khedr, Adly Abdallah Selim, Mohamed Abd El-Motaleb Abd El-Rahman and Wafaa Abdou Zaghary

    Chemistry Central Journal 2016 10:73

    Published on: 28 November 2016

  13. Research article

    Synthesis of acyl oleanolic acid-uracil conjugates and their anti-tumor activity

    Oleanolic acid, which can be isolated from many foods and medicinal plants, has been reported to possess diverse biological activities. It has been found that the acylation of the hydroxyl groups of the A-ring...

    Wei-bin Mo, Chun-hua Su, Jia-yan Huang, Jun Liu, Zhen-feng Chen and Ke-guang Cheng

    Chemistry Central Journal 2016 10:69

    Published on: 21 November 2016

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