Biological Chemistry

This section publishes peer-reviewed open access articles in all areas of biologically- and medically-related chemistry including biochemistry, chemical biology, biotechnology, biomacromolecules, medicinal chemistry, carbohydrate chemistry, and toxicology.

Section Editors: Yasuhiro Nishiyama, Chris Swain and Paul Wrede


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  1. Research article

    Biological effects of a new set 1,2,4-triazolo[1,5-a]quinazolines on heart rate and blood pressure

    Several quinazoline and triazole derivatives are reported to possess a wide-range of interesting pharmacological effects. Although various triazoloquinazoline subclasses having been synthesized and studied, th...

    Rashad Al-Salahi, Kamal-Eldin El-Tahir, Ibrahim Alswaidan, Nabih Lolak, Mohammed Hamidaddin and Mohamed Marzouk

    Chemistry Central Journal 2014 8:3

    Published on: 15 January 2014

  2. Research article

    Ultrasound-assisted lipase-catalyzed synthesis of D-isoascorbyl palmitate: process optimization and Kinetic evaluation

    D-isoascorbic acid is a food antioxidant additive and used in accordance with Good Manufacturing Practice (GMP). High solubility in water (about 150 g/L at 25°C) reduces its effectiveness in stabilizing fats a...

    Feng-Jie Cui, Hong-Xia Zhao, Wen-Jing Sun, Zhuan Wei, Si-Lian Yu, Qiang Zhou and Ying Dong

    Chemistry Central Journal 2013 7:180

    Published on: 9 December 2013

  3. Research article

    Synthesis and biological evaluation of Combretastatin A-4 derivatives containing a 3’-O-substituted carbonic ether moiety as potential antitumor agents

    Combretastatin A-4 (CA-4), which is an excellent antineoplastic agent, was isolated from Combretum caffrum. To date, structural modification studies of CA-4 have focused predominantly on the construction of new t...

    Mingyi Ma, Longru Sun, Hongxiang Lou and Mei Ji

    Chemistry Central Journal 2013 7:179

    Published on: 5 December 2013

  4. Research article

    A fingerprint pair analysis of hERG inhibition data

    Drugs that bind to the human Ether-a-go-go Related Gene (hERG) potassium channel and block its ion conduction can lead to Torsade de Pointes (TdP), a fatal ventricular arrhythmia. Thus, compounds are screened ...

    Clayton Springer and Katherine L Sokolnicki

    Chemistry Central Journal 2013 7:167

    Published on: 21 October 2013

  5. Research article

    In-vitro immunomodulatory and anti-cancerous activities of biotransformed products of Dianabol through Azadirachta indica and its molecular docking studies

    Plant Biotransformation is one of the tools for structural modifications of the organic substrate of low, moderate or high biological value utilizing plant cultured cells, these modifications of organic struct...

    Saifullah, Saifullah Khan, Azizuddin, Sobia Ahsan Halim, Muhammad Kashif, Almas Jabeen, Muhmammad Asif, Muhammad Ahmed Mesaik, Zaheer Ul-Haq, Ahsana Dar and Muhammad Iqbal Choudhary

    Chemistry Central Journal 2013 7:163

    Published on: 7 October 2013

  6. Research article

    Isolation of anticancer constituents from flos genkwa (Daphne genkwaSieb.et Zucc.) through bioassay-guided procedures

    Flos Genkwa (yuanhua in Chinese), the dried flower buds of Daphne genkwa Sieb.et Zucc. (Thymelaeaceae), is a traditional Chinese medicinal herb mainly used for diuretic, antitussive, expectorant, and anticancer e...

    Simeng Li, Guixin Chou, Youcheng Hseu, Hsinling Yang, HiuYee Kwan and Zhiling Yu

    Chemistry Central Journal 2013 7:159

    Published on: 23 September 2013

  7. Review

    Triterpenoid resinous metabolites from the genus Boswellia: pharmacological activities and potential species-identifying properties

    The resinous metabolites commonly known as frankincense or olibanum are produced by trees of the genus Boswellia and have attracted increasing popularity in Western countries in the last decade for their various ...

    Yuxin Zhang, Zhangchi Ning, Cheng Lu, Siyu Zhao, Jianfen Wang, Baoqin Liu, Xuegong Xu and Yuanyan Liu

    Chemistry Central Journal 2013 7:153

    Published on: 12 September 2013

  8. Research article

    Healthy ageing and depletion of intracellular glutathione influences T cell membrane thioredoxin-1 levels and cytokine secretion

    During ageing an altered redox balance has been observed in both intracellular and extracellular compartments, primarily due to glutathione depletion and metabolic stress. Maintaining redox homeostasis is impo...

    Rita Barreto Duarte Carilho Torrao, Irundika HK Dias, Stuart J Bennett, Christopher R Dunston and Helen R Griffiths

    Chemistry Central Journal 2013 7:150

    Published on: 5 September 2013

  9. Review

    Phytochemicals and biological studies of plants in genus Hedysarum

    In China, several species (Hedysarum polybotrys Hand.-Mazz., Hedysarum limprichtii Hlbr., Hedysarum vicioider Turcz. var. Taipeicum Hand.-Mazz. Liu, Hedysarum smithianum, et al.) of genus Hedysarum have a long hi...

    Yinmao Dong, Dongyan Tang, Na Zhang, Yue Li, Chunhong Zhang, Li Li and Minhui Li

    Chemistry Central Journal 2013 7:124

    Published on: 18 July 2013

  10. Research article

    Aromatase and glycosyl transferase inhibiting acridone alkaloids from fruits of Cameroonian Zanthoxylumspecies

    Zanthoxylum zanthoxyloides and Z. leprieurii fruits are commonly used in traditional system of medicine for diarrhea, pain, wound healing, etc. in Cameroon, Africa. Z. leprieurii fruits have been chemically studi...

    Vyry NA Wouatsa, Laxminarain Misra, Shiv Kumar, Om Prakash, Feroz Khan, Francois Tchoumbougnang and R Kumar Venkatesh

    Chemistry Central Journal 2013 7:125

    Published on: 18 July 2013

  11. Research article

    The occurrence of mycotoxins in wheat from western Romania and histopathological impact as effect of feed intake

    The goal of this study has been to evaluate the extent of mycotoxins contamination and their co-occurrence in wheat grain intended for animal feed. A total of 52 wheat samples were collected from the harvest o...

    Ersilia Alexa, Cristina Adriana Dehelean, Mariana-Atena Poiana, Isidora Radulov, Anca-Maria Cimpean, Despina-Maria Bordean, Camelia Tulcan and Georgeta Pop

    Chemistry Central Journal 2013 7:99

    Published on: 10 June 2013

  12. Research article

    The binding characteristics of isoniazid with copper–zinc superoxide dismutase and its effect on enzymatic activity

    Isoniazid (INH) is front-line anti-tuberculosis (TB) drugs, which are usually prescribed to TB patients for a total period of 6 months. Antituberculosis drug-induced hepatotoxicity (ATDH) is a serious adverse ...

    Nana Du, Liangquan Sheng, Zhaodi Liu, Xiaojuan Hu, Huajie Xu and Shuisheng Chen

    Chemistry Central Journal 2013 7:97

    Published on: 6 June 2013

  13. Research article

    Comparison of activity indexes for recognizing enzyme mutants of higher activity with uricase as model

    For screening a library of enzyme mutants, an efficient and cost-effective method for reliable assay of enzyme activity and a decision method for safe recognition of mutants of higher activity are needed. The ...

    Juan Feng, Hongbo Liu, Xiaolan Yang, Ang Gao, Juan Liao, Liping Feng, Jun Pu, Yanling Xie, Gaobo Long, Yuanli Li and Fei Liao

    Chemistry Central Journal 2013 7:69

    Published on: 17 April 2013

  14. Research article

    Synthesis, characterization, in vitro antimicrobial, and U2OS tumoricidal activities of different coumarin derivatives

    Coumarin and its derivatives are biologically very active. It was found that the enhanced activities are dependent on the coumarin nucleus. Biological significance of these compounds include anti-bacterial, an...

    Sadia Rehman, Muhammad Ikram, Robert J Baker, Muhammad Zubair, Effat Azad, Soyoung Min, Kashif Riaz, KH Mok and Saeed-Ur Rehman

    Chemistry Central Journal 2013 7:68

    Published on: 15 April 2013

  15. Research article

    Structural features, kinetics and SAR study of radical scavenging and antioxidant activities of phenolic and anilinic compounds

    Phenolic compounds are widely distributed in plant kingdom and constitute one of the most important classes of natural and synthetic antioxidants. In the present study fifty one natural and synthetic structura...

    Hussein M Ali, Ahmed Abo-Shady, Hany A Sharaf Eldeen, Hany A Soror, Wafaa G Shousha, Osama A Abdel-Barry and Ahmed M Saleh

    Chemistry Central Journal 2013 7:53

    Published on: 16 March 2013

  16. Research article

    Assessment of cigarette smoke particle deposition within the Vitrocell® exposure module using quartz crystal microbalances

    Cigarette smoking is a cause of a variety of serious diseases, and to understand the toxicological impact of tobacco smoke in vitro, whole smoke exposure systems can be used. One of the main challenges of the dif...

    Jason Adamson, David Thorne, Annette Dalrymple, Debbie Dillon and Clive Meredith

    Chemistry Central Journal 2013 7:50

    Published on: 12 March 2013

  17. Research article

    Designing of inhibitors against drug tolerant Mycobacterium tuberculosis (H37Rv)

    Mycobacterium tuberculosis (M.tb) is the causative agent of tuberculosis, killing ~1.7 million people annually. The remarkable capacity of this pathogen to escape the host immune system for decades and then to ca...

    Deepak Singla, Rupinder Tewari, Ashwani Kumar and Gajendra PS Raghava

    Chemistry Central Journal 2013 7:49

    Published on: 8 March 2013

  18. Research article

    Structure-based drug design studies of UDP-N-acetylglucosamine pyrophosphosrylase, a key enzyme for the control of witches’ broom disease

    The witches’ broom disease is a plague caused by Moniliophthora perniciosa in the Theobroma cacao, which has been reducing the cocoa production since 1989. This issue motivated a genome project that has showing s...

    Manoelito C Santos Junior, Sandra Aparecida de Assis, Aristóteles Góes-Neto, Ângelo Amâncio Duarte, Ricardo José Alves, Moacyr Comar Junior and Alex Gutterres Taranto

    Chemistry Central Journal 2013 7:48

    Published on: 5 March 2013

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